Internship M1
The specificity of the adaptive immune system relies on a highly diverse set of lymphocyte receptors. In the work I have done, we quantify how human T cell receptors are distributed across sequence space. We found that the genetic recombination machinery leads to a highly non-uniform but correlated distribution of receptors. These correlations are further amplified by selection, which to a large degree is universal across individuals. Our results help explain a number of recent observations with regards to clustering of receptor sequences, and provide a baseline for the further study of repertoire architecture. Find some more details on the following preprint .